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TIL only 400 out of the 7000 diseases classified as “rare” have an effective treatment. This fact is recognized during Rare Disease Day, which is held every year on the last day of February. This day also holds an extra special meaning on February 29 – the rarest day of the year.

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BrW4K TIL that the most weight gained for a role was 70 lbs (32 kg), which Vincent D'Onofrio did for Pvt. Leonard Lawrence in "Full Metal Jacket." The role was initially written as a "skinny ignorant redneck," but director Stanley Kubrick felt the character would have more impact if he was big and clumsy.
nWJmY TIL about Jesse James biopic made in 1927. His light-hearted portrayal was found inaccurate by those who still remembered him as a vicious murderer, and the movie failed.
rkV4 TIL astronauts on the International Space Station see around 15 sunrises and sunsets every day
5YBe9 TIL within a span of 60 years in the 16th century, 3 epidemics (1 Smallpox and 2 Cocoliztli) killed an estimated 40%, 80% and 50% of the population (at the time) of Mexico. They started with the arrival of the Spanish and particularly targeted the indigenous people. Estimated 25 million deaths.
YpMPG TIL The Show Tom and Jerry first aired in February of 1940 and won Seven Academy awards for Animation for its original run. Even though the original show ended in 1958, spin-offs of the beloved Cat and Mouse have continued through the present day.