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TIL Three generations of the 10th US President John Tyler’s family from his 1790 birth to his still living grandsons have spanned parts of 4 centuries.

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4XPaX TIL of the Sonic Hedgehog Signaling Pathway, which transmits information to embryonic cells required for proper cell differentiation.
4Xwpo TIL that for John Wick: Parabellum (2019) five dogs played Halle Berry's two sidekicks and she did the regular training herself so that on-set, the dogs actually followed her and no one had to give commands from off-camera
0BVL TIL Mel Blanc the voice of Bugs Bunny, voiced Barney Rubble from the Flintstones while he was in full-body cast as he lay flat on his back with the other Flintstones co-stars gathered around him after a car crash.
7rrrr TIL In 2013, Apple banned a game called “Send Me To Heaven” which involved throwing your iPhone as high as you can. The creator wanted to deliberately destroy as many iPhones as possible.
1anvD TIL that just outside Albuquerque you can drive East on Route 66 and hit a rumble strip that plays "America The Beautiful" if you drive the speed limit, turning the wheels of your car into a phonograph