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Urinary dimethyltryptamine and psychiatric symptomatology and classification

Published online by Cambridge University Press:  09 July 2009

R. Rodnight ,
R. M. Murray ,
M. C. H. Oon ,
I. F. Brockington ,
P. Nicholls  and
J. L. T. Birley
R. Rodnight*
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry, London
R. M. Murray
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry, London
M. C. H. Oon
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry, London
I. F. Brockington
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry, London
P. Nicholls
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry, London
J. L. T. Birley
Affiliation:
Departments of Biochemistry and Psychiatry, Institute of Psychiatry, London
*
1Address for correspondence: Dr R. Rodnight, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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Synopsis

The excretion of dimethyltryptamine (DMT) was studied amongst 122 recently admitted psychiatric patients and 20 normal subjects. DMT was detected in the urine of 47% of those diagnosed by their psychiatrists as schizophrenic, 38% of those with other non-affective psychoses, 13% of those with affective psychoses, 19% of those with neurotic and personality disorders and 5% of normal subjects. Ninety-nine patients were interviewed in a semi-standardized fashion, and also categorized according to a variety of operational definitions of the psychoses. The operational definitions failed to reveal any group significantly more correlated with urinary DMT than a hospital diagnosis of schizophrenia, but a discriminant function analysis of symptomatology could be used to define a group of 21 patients of whom 15 (71%) excreted detectable DMT. There was a general relationship between psychotic symptoms and urinary DMT, but specifically schizophrenic symptoms did not appear to be major determinants of DMT excretion.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 4 , February 1977 , pp. 649 - 657
Copyright
Copyright © Cambridge University Press 1977

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References

REFERENCES

Astrachaan, B. M., Harrow, M., Adler, D., Brauer, L., Schwartz, A., Schwartz, C. & Tucker, G. (1972). A checklist for the diagnosis of schizophrenia. British Journal of Psychiatry 121, 529–539.CrossRefGoogle Scholar
Baumann, P. & Narasimhachari, N. (1973). Identification of DMT, 5 MeO-DMT and Bufotenin by cellulose TLC. Journal of Chromatography 86, 269–273.CrossRefGoogle Scholar
Bidder, T. G., Mandel, L. R., Ahn, H. S., VandenHeuval, W. J. A. & Walker, R. W. (1974). Blood and urinary dimethyltryptamine in acute psychotic disorders. Lancet i, 165.CrossRefGoogle Scholar
Boulton, A. A. (1971). Biochemical research in schizophrenia. Nature 231, 22–28.CrossRefGoogle ScholarPubMed
Carpenter, W. T., Strauss, J. S. & Bartko, J. J. (1973). Flexible system for the diagnosis of schizophrenia. Science 182, 1275–1278.CrossRefGoogle ScholarPubMed
Carpenter, W. T., Fink, E. B., Narasimhachari, N. & Himwich, H. E. (1975). A test of the transmethylation hypothesis in acute schizophrenic patients. American Journal of Psychiatry 132, 1067–1071.Google ScholarPubMed
Cohen, S., Nichols, A., Wyatt, R. J. & Pollin, W. (1974). The administration of methionine to chronic schizophrenic patients: a review of ten studies. Biological Psychiatry 8, 209–225.Google ScholarPubMed
Cooper, J. E., Kendell, R. E., Gurland, B. J., Sharpe, L., Copeland, J. R. H. & Simon, R. (1972). Psychiatric Diagnosis in New York and London, Maudsley Monograph no. 20. Oxford University Press: London.Google Scholar
Everitt, B. S. (1968). Moments of the statistics kappa and weighted kappa. British Journal of Mathematical and Statistical Psychology 21, 97–103.CrossRefGoogle Scholar
Feighner, J. P., Robins, E., Guze, S. R., Woodruff, R. A., Winokur, G. & Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry 26, 57–63.CrossRefGoogle ScholarPubMed
Forrest, A. D. & Hay, A. J. (1973). The schizophrenias: operational definitions. British Journal of Medical Psychology 46, 337–346.CrossRefGoogle ScholarPubMed
Friedhoff, A. J. & Van Winkle, E. (1962). Isolation and characterisation of a compound from the urine of schizophrenics. Nature 194, 897–898.CrossRefGoogle Scholar
Himwich, H. E. (1970). Indoleamines and the schizophrenias. In Biochemistry, Schizophrenia and Affective Illness (ed. Himwich, H. E.), pp. 79–122. Williams and Wilkins: Baltimore.Google Scholar
Kaplan, J., Mandel, L. R., Stillman, R., Walker, R. W., VandenHeuval, W. J. A., Gillin, J. C. & Wyatt, R. J. (1974). Blood and urine levels of N, N-dimethyltryptamine following administration of psychoactive dosages to human subjects. Psychopharmacologia (Berlin) 38, 239–245.CrossRefGoogle Scholar
Kasanin, J. (1933). The acute schizo-affective psychoses. American Journal of Psychiatry 13, 97.CrossRefGoogle Scholar
Langfeldt, F. (1937). The Prognosis in Schizophrenia and the Factors influencing the Course of the Disease. Humphrey Melford: London.Google Scholar
Mandel, L. R. (1974). Dimethyltryptamine. Psychopharmacology Bulletin 10 (3), 55–56.Google ScholarPubMed
Mandel, L. R., Ahn, H. E., VandenHeuval, W. J. A. & Walker, R. W. (1972). Indoleamine N-methyltransferase in human lung. Biochemical Pharmacology 21, 1197–1200.CrossRefGoogle Scholar
Mandell, A. J. & Morgan, M. (1971). Indole(ethyl)amine N-methyltransferase in human brain. Nature 230, 85–87.Google ScholarPubMed
Narasimhachari, N., Heller, B., Spaide, J., Karkovec, L., Meltzer, M., Strahilevitz, M. & Himwich, H. E. (1971 a). N, N-dimethylated indoleamines in blood. Biological Psychiatry 3, 21–23.Google ScholarPubMed
Narasimhachari, N., Plaut, J. M. & Leiner, K. Y. (1971 b). Thin-layer and gas–liquid chromatographic methods for the identification and estimation of indoleamines in urine samples. Biochemical Medicine 5, 304–310.CrossRefGoogle Scholar
Narasimhachari, N., Avalos, J., Fujimori, M. & Himwich, H. E. (1972). Studies of drug-free schizophrenics and controls. Biological Psychiatry 5, 311–318.Google Scholar
Osmond, H. & Smythies, J. R. (1952). Schizophrenia: a new approach. Journal of Mental Science 98, 309–315.CrossRefGoogle ScholarPubMed
Pollin, W., Cardon, P. & Kety, S. (1961). Effects of amino acid feedings in schizophrenic patients treated with iproniazide. Science 133, 104–105.CrossRefGoogle Scholar
Randrup, A. & Munkvad, I. (1972). Evidence indicating an association between schizophrenia and dopaminergic hyperactivity in the brain. Orthomolecular Psychiatry 1, 2–7.Google Scholar
Registrar General (1968). A Glossary of Mental Disorders. HMSO: London.Google Scholar
Rodnight, R. (1975). The significance of some biochemical abnormalities in schizophrenia. Acta Neurologica 30, 86–101.Google ScholarPubMed
Saavedra, J. M. & Axelrod, J. (1972). Psychotomimetic N-methylated tryptamine formation in brain in vivo and in vitro. Science 175, 1365–1366.CrossRefGoogle ScholarPubMed
Schneider, K. (1959). General Psychopathology (trans. Hamilton, M. W.), pp. 96–135. Grune and Stratton: New York.Google Scholar
Snyder, S. H., Banerjee, S. P., Yamamura, H. I. & Greenberg, D. (1974). Drugs, neurotransmitters and schizophrenia. Science 184, 1243–1253.CrossRefGoogle ScholarPubMed
Walker, R. W., Ahn, H. S., Albers-Schonberg, G., Mandel, L. R. & VandenHeuval, W. J. A. (1973). Gas chromatographic-mass spectrometeric isotope dilution assay for N, N-dimethyltryptamine in human plasma. Biochemical Medicine 8, 105–113.CrossRefGoogle Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: London.Google Scholar
Wu, P. H. & Boulton, A. A. (1973). Distribution of tryptamine in the rat brain. Canadian Journal of Biochemistry 51, 1104–1112.CrossRefGoogle ScholarPubMed
Wyatt, R. J., Termini, B. & Davis, J. M. (1971). Biochemical and sleep studies of schizophrenia: a review of the literature 1960–1970. Schizophrenia Bulletin 4, 8–66.Google Scholar
Wyatt, R. J., Saavedra, J. M. & Axelrod, J. (1973). A dimethyl-tryptamine-forming enzyme in human blood. American Journal of Psychiatry 130, 754–760.CrossRefGoogle ScholarPubMed